Search results for "Lymphocyte costimulation"

showing 2 items of 2 documents

Microenvironment Regulation of IL23R/IL-23 Axis Drives Chronic Lymphocytic Leukemia (CLL) Progression

2015

Abstract Background : CLL displays a considerable degree of clinical heterogeneity, which is in part ascribable to clone-intrinsic biological features and that are also influenced by clone-extrinsic events related to the microenvironment. Among the dynamics-taking place within the CLL microenvironment, those finalized to the induction of an overly inflammatory milieu may significantly impact on the CLL natural history by hijacking the immunological microenvironment at the same time fostering clone fitness. IL-23 acts as a prototypical pro-inflammatory mediator representing a promising therapeutic target. We analyzed the ability of CLL cells to sense IL-23 through the IL-23R complex (consist…

CD40biologymedicine.diagnostic_testChronic lymphocytic leukemiaImmunologyClone (cell biology)CD28Cell BiologyHematologymedicine.diseaseBiochemistryCD19Flow cytometryLymphocyte costimulationbiology.proteinmedicineCancer researchCD5Blood

researchProduct

FP187MITOCHONDRIAL DYSFUNCTION INDUCED BY TENOFOVIR IN RENAL CELLS. POTENTIATION OF THE EFFECTS BY CO-STIMULATION WITH ANGIOTENSIN II

2015

TransplantationKidneyAngiotensin receptorTenofovirbusiness.industryLong-term potentiationMitochondrionPharmacologyAngiotensin IImedicine.anatomical_structureCo-stimulationNephrologyLymphocyte costimulationMedicinebusinessmedicine.drugNephrology Dialysis Transplantation

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